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10.1016/j.fsi.2006.08.003

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The 17th acute disease quality initiative international consensus conference: Introducing precision renal replacement therapy

Diagnostic criteria Mild hyponatremia: 130135 mEq/L Moderate hyponatremia: 125129 mEq/L Severe hyponatremia: 295 mOsmol/kg H 2 O Causes Hyperglycemia IV mannitol IV radiocontrast use Isotonic hyponatremia [2] [5] Definition: : low measured serum Na + concentration and normal serum osmolality Serum osmolality: 280295 mOsmol/kg H 2 O Causes TURP syndrome [9] Pseudohyponatremia Asymptomatic laboratory artifact falsely indicating hyponatremia when sodium has not been reduced or diluted Due to very high amounts of protein or lipids in the plasma (e.g., hyperlipidemia, multiple myeloma), which then alter the plasma water concentration Clinical features may include: Isotonic hyponatremia should always be excluded as a cause of hyponatremia to avoid unnecessarily aggressive treatment

That is significantly more than semaglutide alone typically achieves